martedì 6 novembre 2012

Test del DNA per scoprire se siamo soggetti al Morbo di Alzheimer

Gli scienziati del Banner Alzheimer's Institute in Arizona, della Boston University e della University of Antioquia hanno studiato 44 adulti di età compresa tra i 18 e 26 anni, sottoponendoli a risonanze magnetiche, analisi del sangue e del liquido cerebrospinale (Csf) scoprendo così che circa il 30% del campione - tutti soggetti senza segni clinici della malattia - aveva nel patrimonio genetico la mutazione di PSEN1 e con ogni probabilità è destinato a sviluppare la malattia neuro-degenerativa in un'età insolitamente giovane, collocata intorno ai 45 anni. Oltre alla gene mutato, i ricercatori hanno anche identificato altri indicatori: i soggetti predisposti alla malattia, ad esempio, presentano un'attività elettrica maggiore nell'ippocampo, area deputata alla memoria, e nel paraippocampo, e una minor volume cerebrale in altre zone del cervello. Altro segnale è la maggiore presenza nel liquido cerebrospinale (Csf) di beta-amiloide, proteina tossica che “soffoca” i neuroni ed è la principale responsabile dello sviluppo dell'Alzheimer, comportando la perdita di memoria e difficoltà cognitive.  

continua... Scovare l'Alzheimer a 20 anni - Salute 24 - Il Sole 24 Ore

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