lunedì 6 ottobre 2008

L'obesità è nel cervello

Fonte: www.corriere.it
r.s. a cura della redazione ECplanet
L'obesità sta nel cervello e non nel piatto.
Sta, per la precisione, in una proteina infiammatoria capace di condizionare direttamente l'assunzione del cibo e quindi l'aumento di peso.
È la prima volta che si dimostra qualcosa del genere e la ricerca pubblicata su Cell, nonostante sia stata condotta sui topi, lascia sperare nella possibilità di percorrere una strada completamente nuova nello studio di farmaci anti-fame e nella messa a punto di sistemi di prevenzione.
Non solo dell'obesità in sé, ma anche delle patologie correlate,come il diabete o le malattie cardiovascolari. L'INFIAMMAZIONE
I ricercatori, un gruppo americano dell'University of Madison-Wisconsin guidato da Dongsheng Cai, si sono focalizzati su un'area cerebrale chiamata ipotalamo, che controlla l'equilibrio di alcuni sistemi dell'organismo, compreso l’appetito e il bilancio energetico, e sull'infiammazione metabolica, un nuovo fenomeno che sembra all'origine di molte malattie come quelle cardiovascolari e anche il diabete.
Non si tratta della «normale» infiammazione che si associa per esempio a un'infezione, a un trauma o un tumore, ma di una infiammazione molto meno evidente ma cronica, che interessa le cellule a livello molecolare. Questo particolare tipo di infiammazione è innescata da alcune proteine e a sua volta mette in moto altre proteine. I ricercatori hanno cercato di capire se il fenomeno dell'infiammazione metabolica potesse in qualche modo essere presente anche nei neuroni del cervello e condizionare l'assunzione di cibo.
COMPLESSI
Studiando i topi, gli esperti hanno dimostrato l'effettiva presenza nel cervello (e in particolare nell'ipotalamo) di un complesso di proteine dell'infiammazione, in sigla NF-kappaB, che può essere attivato da una specifica proteina chiamata IKKbeta, e hanno anche verificato che queste proteine sono più abbondanti qui che nei tessuti periferici dell'organismo.
Hanno però visto che di solito, nel cervello, rimangono inattive.
Quando però l'alimentazione è particolarmente ricca di grassi, il sistema si mette in moto e dà così origine a un circolo vizioso: quanto più si attiva, tanto più aumenta l'appetito e l'introduzione di cibo.
Se invece si blocca la proteina IKKbeta che stimola il sistema (disattivando il gene che la produce), quest'ultimo non si attiva, l'assunzione di cibo diminuisce e i topi non ingrassano. Così questa proteina potrebbe diventare un nuovo bersaglio.
Data articolo: ottobre 2008

12 commenti:

Anonimo ha detto...

China and Russia put the blame on some screwed up experiments of US for the earthquake that happened in Haiti.
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Anonimo ha detto...

China and Russia put the blame on some screwed up experiments of US for the earthquake that happened in Haiti.
Chinese and Russian Military scientists, these reports say, are concurring with Canadian researcher, and former Asia-Pacific Bureau Chief of Forbes Magazine, Benjamin Fulford, who in a very disturbing video released from his Japanese offices to the American public, details how the United States attacked China by the firing of a 90 Million Volt Shockwave from the Americans High Frequency Active Auroral Research Program (HAARP) facilities in Alaska
If we can recollect a previous news when US blamed Russia for the earthquake in Georgio. What do you guys think? Is it really possible to create an earthquake by humans?
I came across this [url=http://universalages.com/hot-news/what-happened-in-haiti-is-it-related-to-haarp/]article about Haiti Earthquake[/url] in some blog it seems very interesting, but conspiracy theories have always been there.

Anonimo ha detto...

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